Leucine and pyridoxine reduce fat by decreasing fat accumulation and increasing fat burning

Leucine + Pyridoxine = increased fat burning + reduced fat accumulation

Leucine is an essential aminoacid known to stimulate muscle protein synthesis and to reduce fat by increasing fat oxidation (fat burning) and growth of mitochondria in muscle and fat cells.

A new research paper shows that the combination of leucine and a form of pyridoxine/vitamin B6 (pyridoxal-L-phosphate) has a direct effect on fat cells and muscle cells alike.

Specifically, in fat cell cultures leucine decreases fatty acid synthase (FAS), an enzyme responsible for the accumulation of fat. As a result fat (triglyceride) accumulation inside the fat cells was also found to be decreased. Combination with pyridoxal-L-phosphate further boosted this effect.

Furthermore, on a clinical trial on 20 overweight people, the combination of the two nutrients increased overall fat oxidation by 300 calories a day (very significant), improved insulin resistance and reduced free radicals and inflammation.

The researchers conclude that the combination of leucine pyridoxal-L-phosphate is "a useful nutraceutical in the management of obesity".


Leucine for cellulite reduction

Previous research has shown that leucine acts against fat accumulation, and this paper builds on this knowledge by proving that leucine also helps increase fat burning, in combination with Vitamin B6 (pyridoxine).

Leucine is one of a number of aminoacids that have a direct anti-lipogenic (fat accumulation-inhibiting) or lipolytic (fat release-stimulating) action on fat cells, and therefore it can be used as an anti-cellulite ingredient, either on it's own or in combination with pyridoxine or other aminoacids. 



  • Journal: Nutrients
  • Article: Effects of a Leucine and Pyridoxine-Containing Nutraceutical on Fat Oxidation, and Oxidative and Inflammatory Stress in Overweight and Obese Subjects
  • Link: http://www.mdpi.com/2072-6643/4/6/529
  • Excerpt: "These data indicate that the active blend significantly increased fat oxidation and insulin sensitivity, and reduced oxidative and inflammatory stress. Therefore, the active blend appears to be a useful nutraceutical in the management of obesity and associated co-morbidities"